Which Meds Can Cause Sexual Dysfunction in Men?

There is a long list of medications that cause sexual dysfunction as an unwanted side effect. Find out which ones might be causing your symptoms so that you can talk with your medical provider about available solutions.

Published on
June 21, 2023
Author
Dr. Ken Bains
Chief of Pharmacy
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Your doctor prescribed you a new medication and you started it immediately, as instructed, hoping for an improved quality of life by treating your condition the medication was prescribed for… but now, you’re starting to notice some new problems in the bedroom.

Sexual dysfunction could be a side effect of the medication you’re on.

Prescription pharmaceutical treatments can improve your life,even save it. However, they sometimes come with sexual dysfunction as an unwanted side effect.

 

Sexual dysfunction in men is defined as any physical or psychological problem that prevents you or your partner from getting sexual satisfaction. Some examples in men include, but are not limited to:

·     Erectile dysfunction

·     Decreased sexual desire

·     Ejaculation difficulties

·     Painful erections

 

Medications that can cause sexual dysfunction in men include a variety of types, such as SSRIs and other psychotropic medications.

The following list shows exactly which medications cause sexual dysfunction in men, what kinds of sexual dysfunction they cause, the severity of the dysfunction, and the commonness of these side effects.

3 column table: DRUGS ASSOCIATED WITH SEXUAL DYSFUNCTION IN MEN *** = higher risk for sexual dysfunction Brand Name	Generic Name	Effects Reported Adalat	nifedipine	Erectile dysfunction Adapin	doxepin	Decreased sexual desire; ejaculation difficulties Aldactone***	spironolactone	Decreased sexual desire; erectile dysfunction Aldomet	methyldopa	Decreased sexual desire; ejaculation difficulties (retrograde ejaculation); erectile dysfunction (rare) Altace	ramipril	Erectile dysfunction (rare) Anafranil***	clomipramine	Erectile dysfunction; ejaculation difficulties (common); orgasm triggered by yawning Anaprox	naproxen	Erectile dysfunction Apresoline	hydralazine	Erectile dysfunction (uncommon) Ativan	lorazepam	Decreased sexual desire Aventyl	nortriptyline	Decreased sexual desire; erectile dysfunction Avodart	dutasteride	Erectile dysfunction Blocadren***	timolol	Erectile dysfunction (uncommon); decreased sexual desire Bumex	bumetanide	Premature ejaculation; erectile dysfunction (rare) BuSpar	buspirone	Change in sexual desire (uncommon); erectile dysfunction (rare); delayed ejaculation (rare)
Calan	verapamil	Erectile dysfunction (uncommon) Capoten	captopril	Erectile dysfunction (uncommon) Cardene	nicardipine	Erectile dysfunction (rare) Cardizem	diltiazem	Decreased sexual desire; erectile dysfunction (rare) Cardura	doxazosin	Abnormal ejaculation (retrograde ejaculation or diminished ejaculation); priapism Cartrol***	carteolol	Erectile dysfunction Catapress	clonidine	Decreased sexual desire; erectile dysfunction; slowed ejaculation; trouble ejaculating (retrograde ejaculation)  Clozaril	clozapine	Erectile dysfunction; prolonged painful erection Congentin	benztropine	Erectile dysfunction Combipres	chlorthalidone/clonidine	Erectile dysfunction; decreased sexual desire; less sexual activity; trouble ejaculating (retrograde ejaculation) Compazine	prochlorperazine	Erectile dysfunction; ejaculation problems; prolonged painful erection Corgard***	nadolol	Decreased sexual desire, erectile dysfunction Cytotec	misoprostol	erectile dysfunction; decreased sexual desire (both rare) Desyrel	trazadone	Prolonged painful erection; change in sexual desire; ejaculation difficulties Diamox	acetazolamide	Erectile dysfunction; decreased sexual desire Bibenzyline	phenoxybenzamine	Ejaculation difficulties Dilantin	phenytoin	Decreased sexual desire; erectile dysfunction; prolonged and painful erection
Ditropan	oxybutynin	Erectile dysfunction Dolophine	methadone	Decreased sexual desire; erectile dysfunction; no orgasm (retrograde ejaculation); delayed ejaculation Donnatal	phenobarbital/hyoscyamine	Erectile dysfunction Dopar	levodopa	Increased sexual desire Dyazide	hydrochlorothiazide/triamterene	Erectile dysfunction; trouble ejaculating (retrograde ejaculation) Elavil	amitriptyline	Decreased sexual desire; erectile dysfunction; no ejaculation (retrograde ejaculation)  Eldepryl	selegiline	Sexual difficulties Endep	amitriptyline	Decreased sexual desire; erectile dysfunction; no ejaculation (retrograde ejaculation)  Esidrix	hydrochorothiazide	Erectile dysfunction, trouble ejaculating (retrograde ejaculation) Eskalith	lithium	Sexual difficulties; erectile dysfunction Flomax	tamsulosin	Abnormal ejaculation (retrograde ejaculation or diminished ejaculation) Folex	tamsulosin	Loss of sexual desire; erectile dysfunction Haldol	haloperiodol	Erectile dysfunction; change in sexual desire; painful ejaculation; prolonged painful erection Hydrodiuril	hydrochlorothiazide	erectile dysfunction; problem with ejaculation (retrograde ejaculation) Hytrin	terazosin	Abnormal ejaculation (retrograde ejaculation or diminished ejaculation); priapism  Inderal***	propranolol	Loss of sexual desire; erectile dysfunction (rare)
Isoptin	verapamil	Erectile dysfunction (uncommon) Lanoxin	digoxin	Decreased sexual desire; erectile dysfunction Larodopa	levodopa	Increased sexual desire; prolonged & painful erection  Lithobid	lithium	Erectile dysfunction Lioresal	baclofen	Erectile dysfunction; abnormal ejaculation (retrograde ejaculation) Lopid	gemfibrozil	Decreased sexual desire; erectile dysfunction Lopressor	metoprolol	Erectile dysfunction Lupron***	leuprolide	Erectile dysfunction (common); decreased sexual desire; hot flashes (suppresses testicular steroidogenesis)  Megace	megestrol	Change in sexual desire; trouble with orgasm  Mellaril	thioridazine	Change in sexual desire; erectile dysfunction; prolonged, painful erection; trouble with orgasm (retrograde ejaculation)  Minipress	prazosin	Abnormal ejaculation (retrograde ejaculation or diminished ejaculation); priapism  Mysoline	primidone	Change in sexual desire; erectile dysfunction (uncommon) Naprosyn	naproxen	Erectile dysfunction; trouble ejaculating (retrograde ejaculation)  Nizoral	ketoconazole	Erectile dysfunction; decreased sexual desire  Normodyne***	labetolol	Erectile dysfunction; ejaculation problems; decreased sexual desire; painful & prolonged erection Norpramin	desipramine	Erectile dysfunction; decreased sexual desire; trouble with orgasm Oretic	hydrochlorothiazide	Erectile dysfunction; trouble ejaculating (retrograde ejaculation)
Pamelor	nortriptyline	Erectile dysfunction; decreased sexual desire Pepcid	famotidine	Erectile dysfunction (rare) Petrofrane	despramine	Erectile dysfunction; decreased sexual desire; trouble with orgasm Prinivil	lisinopril	Erectile dysfunction (rare) Pro-Banthine	propantheline	Erectile dysfunction  Procardia	nifedipine	Erectile dysfunction Propecia	finasteride	Erectile dysfunction Prozac	fluoxetine	Decreased sexual desire; problems with orgasm ejaculation (retrograde ejaculation); erectile dysfunction (rare) Rapaflo	filodosin	Abnormal ejaculation (retrograde ejaculation or diminished ejaculation); prolonged, painful erection  Reglan	metoclopramide	Decreased sexual desire; erectile dysfunction Rheumatrex	methotrexate	Loss of sexual desire; erectile dysfunction  Robinul	glycopyrrolate	Erectile dysfunction Rocaltrol	calcitriol	Lower sexual desire  Serax	oxazepam	Change in sexual desire  Sinemet	carbidopa/levodopda	Increased sexual desire; prolonged painful erection Sinequan	doxepin	Decreased sexual desire; ejaculation difficulties  Tagamet	cimetidine	Decreased sexual desire; erectile dysfunction
Tegretol	carbamazepine	Erectile dysfunction Tenormin***	atenolol	Erectile dysfunction (uncommon) Thorazidine	chlorpromazine	Decreased libido; erectile dysfunction; prolonged painful erection; no ejaculation (retrograde ejaculation)  Timoptic***	timolol	Decreased sexual desire; erectile dysfunction  Tofranil	imipramine	Decreased sexual desire; erectile dysfunction; trouble with orgasm (retrograde ejaculation)  Trandate***	labetalol	Erectile dysfunction; ejaculation problems; less sexual desire; painful & prolonged erection Valium	diazepam	Decreased sexual desire; erectile dysfunction; ejaculation difficulties  Vasotec	enalapril	Erectile dysfunction (rare)  Verelan	verapamil	Erectile dysfunction (uncommon) Voltaren	diclofenac	Erectile dysfunction (rare)  Xanax	alprazolam	Decreased sexual desire; ejaculation difficulties  Zantac	ranitidine	Decreased sexual desire; erectile dysfunction (occasional) Zestril	lisinopril	Erectile dysfunction (rare)  Zoloft	sertraline	Decreased sexual desire; erectile dysfunction; trouble with orgasm (retrograde ejaculation)

If you see your medication on this list, and you’re noticing unwanted symptoms of sexual dysfunction, there’s still hope for your sex life.

The solution can be as simple as adjusting your dose or switching to an alternative medication. But the only way to find a solution is to talk to your doctor. Begin with a thorough physical and evaluation of your medical history, including a complete list of medications.

This is your health. This is your quality of life. This is important.

 

Please note, this article is not intended to replace a medical consultation with your doctor. All health concerns should be brought to a medical professional.

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